Poisoned Lottery Winner's Exhumation Approved

A judge has approved the exhumation of the Chicago lottery winner who died of cyanide poisoning.

Judge Susan Coleman of the Probate Division of the Cook County Circuit Court in Illinois today approved the county medical examiner's request to exhume the body of Urooj Khan at Rosehill Cemetery in Chicago.

Khan, 46, died July 20, 2012, from what was initially believed to be natural causes. But a family member whose identity has yet to be revealed asked the medical examiner's office to re-examine the cause of death, which was subsequently determined to be cyanide poisoning.

The office did so by retesting fluid samples that had been taken from Khan's body, including tests for cyanide and strychnine.

In explaining the request for exhumation, Chief Medical Examiner Stephen Cina has said, "If or when this goes to court, it would be nice to have all the data possible."

The Chicago businessman had won a $1 million lottery jackpot -- before taxes -- the month before he died.

In Photos: Biggest Lotto Winners

In the latest legal twist, Khan's brother filed a petition Wednesday to a judge asking Citibank to release information about Khan's assets to "ultimately ensure" that [Khan's] minor daughter "receives her proper share." Khan reportedly did not have a will.

He left behind a widow, Shabana Ansari, 32, and a teenage daughter from his first marriage. Ansari and Khan reportedly married 12 years ago in India.

Authorities questioned Ansari in November and searched the home she shared with Khan. She and her attorney, Al Haroon Husain, say she had nothing to do with his death.

"It's sad that I lost my husband," she told ABC News. "I love him and I miss him. That's all I can say."

The siblings of the poisoned lottery winner have pursued legal action to protect their niece's share of her late father's estate. They also questioned whether he and Ansari were legally married, but Ansari's attorney said she has a marriage certificate from India that is valid in the United States.

ImTiaz Khan, 56, Khan's brother, and Meraj Khan, 37, their sister, had won a court order to freeze the lottery winnings after Ansari cashed the check.

Husain said Ansari cashed the lottery check after it was mailed to the home, which she did not request.

The lottery check, about $425,000 in cash, was issued July 19 by the Illinois Comptroller's Office, then mailed, according to Brad Hahn, spokesman for the Comptroller's Office. Hahn said it was cashed Aug. 15, nearly a month after Khan's death, but he did not know who cashed it.

The judge later approved Ansari's competing claim as an administrator of the estate.

"I don't care what they talk [sic]," Ansari told ABC News of what her in-laws are saying.

Ansari said she was married to Khan but declined to comment to ABC News about cashing the check after his death, although The Associated Press has reported that she denied removing any of the assets.

Meraj Khan filed in September to become the legal guardian of her niece. After the judge asked the 17-year old daughter with whom she wished to live, she chose her aunt and has been there since November, Husain said.

Neither sibling has petitioned to obtain a share of the dead man's estate, which is estimated to be $1.2 million in lottery winnings, real estate, Khan's laundry business and automobiles.

Neither the attorney for ImTiaz Khan nor the two siblings has responded to requests for comment.

A status hearing on the future of the estate is scheduled for Jan. 24, according to the AP.

ABC News' Alex Perez and Matthew Jaffe contributed to this report.

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String of bombings kill 101, injure 200 in Pakistan

QUETTA, Pakistan (Reuters) - At least 101 people were killed in bombings in two Pakistani cities on Thursday in one of the country's bloodiest days in recent years, officials said, with most casualties caused by sectarian attacks in Quetta.

The bombings underscored the myriad threats Pakistani security forces face from homegrown Sunni extremist groups, the Taliban insurgency in the northwest and the less well-known Baloch insurgency in the southwest.

On Thursday evening, two coordinated explosions killed at least 69 people and injured more than 100 in Quetta, the provincial capital of Balochistan, said Deputy Inspector of Police Hamid Shakil.

The first attack, in a crowded snooker hall, was a suicide bombing, local residents said. About ten minutes later, a car bomb exploded, they said. Five policemen and a cameraman were among the dead from that blast.

The attacks happened in a predominately Shia neighborhood and banned sectarian group Lashkar-e-Jhangvi claimed responsibility. The extremist Sunni group targets Shias, who make up about 20 percent of Pakistani's population.

Targeted killings and bombings of Shia communities are common in Pakistan, and rights groups say hundreds of Shia were killed last year. Militant groups in Balochistan frequently bomb or shoot Shia passengers on buses travelling to neighboring Iran.

The killers are rarely caught and some Shia activists say militants work alongside elements of Pakistan's security forces, who see them as a potential bulwark against neighboring India.

Many Pakistanis fear their nation could become the site of a regional power struggle between Saudi Arabia, source of funding for Sunni extremist groups, and Iran, which is largely Shia.

But sectarian tensions are not the only source of violence.

The United Baloch Army claimed responsibility for a blast in Quetta's market earlier in the day. It killed 11 people and injured more than 40, mostly vegetable sellers and secondhand clothes dealers, police officer Zubair Mehmood said. A child was also killed.

The group is one of several fighting for independence for Balochistan, an arid, impoverished region with substantial gas, copper and gold reserves, which constitutes just under half of Pakistan's territory and is home to about 8 million of the country's population of 180 million.

SWAT BOMBING

In another incident Thursday, 21 were killed and more than 60 injured in a bombing when people gathered to hear a religious leader speak in Mingora, the largest city in the northwestern province of Swat, police and officials at the Saidu Sharif hospital said.

"The death toll may rise as some of the injured are in critical condition and we are receiving more and more injured people," said Dr. Niaz Mohammad.

It has been more than two years since a militant attack has claimed that many lives in Swat.

The mountainous region, formerly a tourist destination, has been administered by the Pakistani army since their 2009 offensive drove out Taliban militants who had taken control.

But Talibans retain the ability to attack in Swat and shot schoolgirl campaigner Malala Yousufzai in Mingora last October.

A Taliban spokesman said they were not responsible for Thursday's bombing.

(Additional reporting by Jibran Ahmad in Peshawar, Pakistan; Writing by Katharine Houreld; Editing by Mark Heinrich and Jason Webb)

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US focused on Syria's chemical arms after Assad: Panetta

WASHINGTON: The United States is increasingly focused on how to secure Syria's chemical weapons if President Bashar al-Assad falls from power but is not considering sending ground troops into the war-torn country, Defense Secretary Leon Panetta said Thursday.

While the US government has issued stern warnings to Damascus against resorting to such arms in its war with rebel forces, Panetta said that a more likely scenario might be a chaotic vacuum if Assad is toppled, with uncertainty over who controls the lethal weapons.

"I think the greater concern right now is what steps does the international community take to make sure that when Assad comes down, that there is a process and procedure to make sure we get our hands on securing those sites," Panetta told a news conference. "That I think is the greater challenge right now."

The US government was discussing the issue with Israel and other countries in the region, he said, but ruled out deploying American ground forces in a "hostile" setting.

"We're not talking about ground troops," Panetta added.

The US military's top officer, General Martin Dempsey, told the same news conference that if Assad chose to use his chemical stockpiles against opposition forces, it would be virtually impossible to stop him.

Preventing the launch of chemical weapons "would be almost unachievable... because you would have to have such clarity of intelligence, you know, persistent surveillance, you would have to actually see it before it happened," he said. "And that's unlikely, to be sure."

He said that clearly worded warnings to Assad from President Barack Obama have served as a deterrent.

Even if the regime chooses not to employ the weapons, the Obama administration worries that Islamist militants allied with rebel forces might gain control of some chemical sites.

Syria's chemical weapons stockpile, which dates back to the 1970s, is the biggest in the Middle East, but its precise scope remains unclear, according to analysts.

The country has hundreds of tons of various chemical agents, including sarin and VX nerve agents, as well as older blistering agents such as mustard gas, dispersed in dozens of manufacturing and storage sites, experts say.

But it remains unclear if the chemical weapons are mounted and ready to be launched on Scud missiles, if the chemical agents are maintained effectively, and whether the regime is able to replenish its chemical stocks.

Damascus has said it might use its chemical weapons if attacked by outsiders, although not against its own people.

Panetta's comments came as prospects for international diplomacy to halt the violence in Syria appeared bleak.

The regime blasted the UN-Arab League envoy, Lakhdar Brahimi, a day before he was due to hold talks with US and Russian officials, accusing him of "flagrant bias."

The 21-month civil war has claimed more than 60,000 lives, according to the United Nations.

- AFP/jc

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Govt raises financial aid for rural housing

NEW DELHI: The Centre has increased the amount for construction of houses for rural poor from Rs 45,000 to Rs 70,000 in plains and Rs 75,000 for those in hilly and difficult areas.

The landless would get Rs 20,000 in place of the present Rs 10,000 for buying homestead land.

The hike in Indira Awas Yojana came after Cabinet members on Thursday prevailed upon finance minister P Chidambaram who wanted to restrict the proposal from rural development ministry to Rs 65,000 per unit and opposed the hike for buying homestead land.

The issue brought to the fore the difference between the two arms of UPA, with rural development minister Jairam Ramesh telling reporters that finance ministry was overruled by the Cabinet. "The Union Cabinet in its overall collective wisdom decided to increase the amount," he said.

Ramesh cited the agreement signed with Ekta Parishad that stopped marching tribals in Agra in October last year. The protestors were seeking land for the landless and the Centre agreed to bear 75% of the cost for buying homestead land in place of present 50%.

There was overwhelming support in the Cabinet for increase in IAY unit cost with Ghulam Nabi Azad, Harish Rawat and Pavan Bansal pitching on other aspects of the debate.

Water resources minister Rawat said Rs 75,000 was inadequate for IAY houses in the hills since land was scarce. He demanded that construction cost be decided according to the cost of land.

Members also complained that while the Centre was funding liberally, the states changed the names of schemes to suit their political ends. The ambulance-on-demand scheme was cited as an example — it has been renamed by states though it is a centrally funded scheme under NRHM.

Briefing reporters, Chidambaram urged states to furnish lists of beneficiaries to banks to enable them to avail loans up to Rs 20,000 at 4% interest. He said loans were not being availed despite the provision for IAY.

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Flu season strikes early and, in some places, hard

NEW YORK (AP) — From the Rocky Mountains to New England, hospitals are swamped with people with flu symptoms. Some medical centers are turning away visitors or making them wear face masks, and one Pennsylvania hospital set up a tent outside its ER to deal with the feverish patients.

Flu season in the U.S. has struck early and, in many places, hard.

While flu normally doesn't blanket the country until late January or February, it is already widespread in more than 40 states, with about 30 of them reporting some major hotspots. On Thursday, health officials blamed the flu for the deaths of 20 children so far.

Whether this will be considered a bad season by the time it has run its course in the spring remains to be seen.

"Those of us with gray hair have seen worse," said Dr. William Schaffner, a flu expert at Vanderbilt University in Nashville.

The evidence so far points to a moderate season, Schaffner and others say. It looks bad in part because last year was unusually mild and because the main strain of influenza circulating this year tends to make people sicker and really lay them low.

David Smythe of New York City saw it happen to his 50-year-old girlfriend, who has been knocked out for about two weeks. "She's been in bed. She can't even get up," he said.

Also, the flu's early arrival coincided with spikes in a variety of other viruses, including a childhood malady that mimics flu and a new norovirus that causes vomiting and diarrhea, or what is commonly known as "stomach flu." So what people are calling the flu may, in fact, be something else.

"There may be more of an overlap than we normally see," said Dr. Joseph Bresee, who tracks the flu for the Centers for Disease Control and Prevention.

Most people don't undergo lab tests to confirm flu, and the symptoms are so similar that it can be hard to distinguish flu from other viruses, or even a cold. Over the holidays, 250 people were sickened at a Mormon missionary training center in Utah, but the culprit turned out to be a norovirus, not the flu.

Flu is a major contributor, though, to what's going on.

"I'd say 75 percent," said Dr. Dan Surdam, head of the emergency department at Cheyenne Regional Medical Center, Wyoming's largest hospital. The 17-bed emergency room saw its busiest day ever last week, with 166 visitors.

The early onslaught has resulted in a spike in hospitalizations. To deal with the influx and protect other patients from getting sick, hospitals are restricting visits from children, requiring family members to wear masks and banning anyone with flu symptoms from maternity wards.

One hospital in Allentown, Pa., set up a tent this week for a steady stream of patients with flu symptoms. But so far "what we're seeing is a typical flu season," said Terry Burger, director of infection control and prevention for the hospital, Lehigh Valley Hospital-Cedar Crest.

On Wednesday, Boston declared a public health emergency, with the city's hospitals counting about 1,500 emergency room visits since December by people with flu-like symptoms.

All the flu activity has led some to question whether this year's flu shot is working. While health officials are still analyzing the vaccine, early indications are that it's about 60 percent effective, which is in line with what's been seen in other years.

The vaccine is reformulated each year, based on experts' best guess of which strains of the virus will predominate. This year's vaccine is well-matched to what's going around. The government estimates that between a third and half of Americans have gotten the vaccine.

In New York City, 57-year-old Judith Quinones suffered her worst case of flu-like illness in years and was laid up for nearly a month with fever and body aches. "I just couldn't function," she said.

She decided to skip getting a flu shot last fall. But her daughter got the shot. "And she got sick twice," Quinones said.

Europe is also suffering an early flu season, though a milder strain predominates there. Flu reports are up, too, in China, Japan, the West Bank, the Gaza Strip, Algeria and the Republic of Congo. Britain has seen a surge in cases of norovirus.

On average, about 24,000 Americans die each flu season, according to the CDC.

Flu usually peaks in midwinter. Symptoms can include fever, cough, runny nose, head and body aches and fatigue. Some people also suffer vomiting and diarrhea, and some develop pneumonia or other severe complications.

Most people with flu have a mild illness and can help themselves and protect others by staying home and resting. But people with severe symptoms should see a doctor. They may be given antiviral drugs or other medications to ease symptoms.

Flu vaccinations are recommended for everyone 6 months or older. Of the 20 children killed by the flu this season, only two were fully vaccinated.

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AP Medical Writer Maria Cheng in London contributed to this report.

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Online:

CDC flu: http://www.cdc.gov/flu/index.htm

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Jodi Arias' Lies Detailed at Murder Trial

The jury in the Jodi Arias murder trial watched a television interview today in which Arias said "no jury will convict me" for killing her ex-boyfriend, Travis Alexander.

Arias also said she could never imagine commiting such a violent act as killing Alexander.

"I understand all the evidence is really compelling," she said in the interview. "In a nutshell, two people came in and killed Travis. I've never even shot a gun. That's heinous. I can't imagine slitting anyone's throat."

She went on to tell the interviewer, "No jury will convict me and you can mark my words on that... I am innocent."

Arias made the statements to the television show Inside Edition after she was indicted for murdering Alexander. Months later, she would confess to killing him in his Mesa, Ariz., home and say it was in self-defense.

Jodi Arias Trial: Watch Live

Jodi Arias Murder Trial: Full Coverage

Photos of Key Players and Evidence in the Jodi Arias Murder Trial

The tape was played on the fifth day of testimony in Arias's trial, in which police allege that she carried out the murder with such brutal force that she stabbed Alexander 27 times, slashed his throat from ear to ear, and shot him in the head.

Arias, now 32, claims Alexander was a controlling and abusive "sexual deviant" who she was forced to kill in self-defense.

She could face the death penalty if convicted of Alexander's murder.

Jodi Arias Trial: Jurors See Photos of Bloody Handprint Watch Video

Jodi Arias Murder Trial: Who Is the Alleged Killer? Watch Video

Jodi Arias Trial: Defense Claims Victim Was Sex Deviant Watch Video

The jury also watched as dozens of photos of blood-spattered walls, flooring, stained carpets and blood smeared sink were explained in detail by a forensic analyst from the Mesa police department, who noted that on many of the stains, water had been mixed with the blood and diluted it.

The prosecution alleges that Arias tried to wash away the evidence of the killing with water.

Prosecutors spent much of today and Wednesday using Arias' recorded statements and other testimony to prove that she lied about her relationship with Alexander, where she was when Alexander was killed, and even where she worked as a bartender.

The testimony today showed that Arias had lied to her new boyfriend Ryan Burns about working at a bar called Margaritaville in her hometown of Yreka, Calif.

"Is there any restaurant in Yreka called Margaritaville? Has there ever been?" prosecutor Juan Martinez asked Nathaniel Mendes, a former detective with the Siskiyou County Sheriff's Office in California.

"No, sir," Mendes replied.

Mendes testified that Arias worked at a restaurant called Casa Ramos in Yreka, not a Margaritaville bar that she told Burns. Mendes also went over receipts showing that Arias rented a car the day before she killed Alexander, and noted that she went to a rental outfit 90 miles from her hometown despite two businesses that rented cars in Yreka.

Arias told friends and investigators that she rented a car to go on a road trip to visit Burns, in West Jordan, Utah, on June 3, 2008. She showed up to Burns' house a day late with cuts on her hands, but told Burns that she got lost driving and that the cuts were from broken glass at her Margaritaville bar tending job, according to Burn's testimony Wednesday.

The trail of receipts showed that Arias drove from California to Alexander's hometown of Mesa on Tuesday, June 4, 2008.

There, the pair had sex and took sexually graphic photos of one another, according to photographs and the opening statement of Arias' lawyer. Shortly after the tryst, Arias killed Alexander, both sides agree.

Burns testified that Arias never mentioned going to Alexander's house when she arrived at his home in Utah. He said he did not know that Arias and Alexander were still sexually involved, and that she told him they had broken up.

When she arrived at his home, just 24 hours after killing Alexander, she seemed "normal," he said. The pair kissed and cuddled, and went out with Burns' friends, where she laughed and made conversation.

Prosecutors have also played recorded phone conversations between detectives and Arias in the weeks after Alexander's body was found. She can be heard lying multiple times to investigators as they ask about the last time she spoke with Alexander and her trip to Utah.

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Venezuela court endorses Chavez inauguration delay

CARACAS (Reuters) - Venezuela's top court endorsed the postponement of Hugo Chavez's inauguration this week and ruled on Wednesday that the cancer-stricken president and his deputy would continue in their roles, despite a cacophony of opposition complaints.

Critics had argued the 58-year-old's absence from his own swearing-in ceremony on January 10 meant a caretaker president must be appointed. Chavez has not been seen in public nor heard from in almost a month following surgery in Cuba.

"Right now we cannot say when, how or where the president will be sworn in," Supreme Court Chief Judge Luisa Morales told a news conference.

"As president re-elect there is no interruption of performance of duties ... The inauguration can be carried out at a later date before the Supreme Court."

The decision opens the door in theory for Chavez to remain in office for weeks or months more from a Cuban hospital bed - though there is no evidence he is even conscious.

It leaves the South American country in the hands of Vice President Nicolas Maduro, as de facto leader of the government.

The opposition say that is a brazen violation of the constitution, and that Maduro should leave office on Thursday when the current presidential term had been due to expire.

They say National Assembly boss Diosdado Cabello, another powerful Chavez ally, should take over the running of the country while new elections would be organized within 30 days.

Maduro would be the ruling Socialist Party's candidate.

Government leaders insist Chavez, 58, is fulfilling his duties as head of state, even though official medical bulletins say he suffered complications after the surgery, including a severe lung infection, and has had trouble breathing.

His resignation or death would transform politics in the OPEC nation, where he is revered by poor supporters thankful for his social largesse, but denounced by opponents as a dictator.

RALLY PLANNED FOR THURSDAY

Moody's Investors Service warned on Wednesday that Venezuela's sovereign credit rating, already at junk status, faces short-term risks over any political transition.

Prices of Venezuela's widely traded bonds have soared lately on Chavez's health woes, but dipped this week as investors' expectations of a quick government change apparently dimmed.

The president has undergone four operations, as well as weeks of chemotherapy and radiation treatment, since being diagnosed with an undisclosed type of cancer in his pelvic area in June 2011.

He looked to have staged a remarkable recovery from the illness last year, winning a new six-year term at a hard-fought election in October. But within weeks of his victory he had to return to Havana for more treatment.

The government has called for a huge rally outside the Miraflores presidential palace in Caracas on Thursday, and allied leaders including Uruguay's Jose Mujica and Bolivia's Evo Morales have said they will visit - despite Chavez's absence.

Argentine President Cristina Fernandez, a close friend, has announced plans to visit Chavez in Cuba on Friday.

The unprecedented silence by Chavez, who is well known for his hours-long rambling speeches, has convinced many Venezuelans that his 14 years in power may be coming to an end.

Unlike after his previous operations in Cuba, no photographs have been published of him recuperating, and social media in Venezuela is buzzing with rumors he is on life support.

Cabello, the pugnacious head of the National Assembly, has repeatedly ruled out taking over as caretaker president to order a new presidential election, saying Chavez remains in charge.

"Tomorrow we will all go to the Miraflores palace," he told a televised Socialist Party meeting on Wednesday. "The people will be invested as president. We are all Chavez!"

(Additional reporting by Marianna Parraga and Diego Ore; Editing by Andrew Cawthorne)

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Football: Swansea stun Chelsea in fresh League Cup shock

LONDON: Swansea produced the second surprise English League Cup semi-final first leg result after defeating Chelsea 2-0 at the European champions' Stamford Bridge ground on Wednesday.

Though not as great an upset as fourth-tier Bradford City's 3-1 defeat of Premier League Aston Villa on Tuesday, Swansea's victory over their top flight rivals was still a surprise.

Both Swansea goals in a backs-to-the-wall effort came as a result of two errors by Chelsea defender Branislav Ivanovic.

In-form Spanish striker Michu, signed for just £2 million from La Liga side Rayo Vallecano, scored his 16th goal of the season in the 39th minute with a curling shot from the edge of the box after Ivanovic miscontrolled the ball.

Chelsea boss Rafael Benitez brought Frank Lampard and Demba Ba off the bench in search of an equaliser but none came.

And in stoppage time, shortly after Ba had had a penalty appeal turned down on his home debut, Swansea's Danny Graham scored for the fourth match in a row after another Ivanovic mistake.

Now Welsh side Swansea will look to seal the tie in the second leg at the Liberty Stadium on January 23, with the prospect of an improbable final against Bradford in their sights.

"We've had some historic results already this season but to win here is very special," Swansea manager Michael Laudrup told Sky Sports.

"We had to defend a lot, they had a lot of possession but to be honest they only had three good chances all night," the Denmark great added.

"They gave us two goals but you have to score them. It was a marvellous fight, we are a team that always try to play but when you play the European champions away you have to change.

"There is still a mountain to climb, Chelsea have so much quality. We will have to play with the same intensity, they can still win and can score three or four goals against us."

- AFP/jc

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Maoist tactic during Latehar gunbattle evokes memories of acclaimed Bosnian war film

NEW DELHI: In an action reminiscent of a scene from Oscar-winning Bosnian war film "No Man's Land", Naxalites in Latehar district of Jharkhand put the body of a critically injured and incapacitated jawan over a landmine following a fierce battle between the Maoists and Central Reserve Police Force (CRPF) on Monday morning. On Tuesday evening, security forces along with local villagers found the jawan's body deep in Karmatiya jungles. However, as soon as the body was picked up, the mine exploded, killing three villagers and blasting the jawan to smithereens.

The death toll of forces in the encounter has now risen to 10, including a jawan from Jharkhand Jaguars. However, a senior CRPF official, alluding to the landmine blast, put the figures rather tragically. "We can confirm the death of 10 jawans. However, we have found only nine bodies so far," he told TOI.

The film No Man's Land had ended with an injured Bosnian soldier lying on the mine while still alive with no hope of rescue. Bosnian Serbs had put his body over a landmine while he was unconscious.

Sources said, in all probability the jawan bled to death while lying on the mine adding that even if he had gained consciousness and tried to move, he would have died. Following the blasts, the forces retreated on Tuesday night and the combing operation was restarted with reinforcements on Wednesday.

On the trail of senior CPI (Maoist) leader Arvindji, around 300 soldiers from CRPF and Jharkhand Jaguars were combing Karmatiya forests when they were ambushed by a contingent of around 200 Maoists — led by a woman — who were firing at them from hill top. The forces had taken the only narrow path that cut through the jungle and then opened into a plain with hills surrounding it. That the Maoists were in Army fatigues confounded matters. About 600 Maoists are suspected to be hiding in the jungles moving between Bihar and Jharkhand.

The government, however, is not perturbed by the deaths as the operation is part of a "fight-to-finish" war to flush out Maoists from Latehar and Chhattisgarh's Sukma districts. "Maoists have been considerably weakened as is evident from constantly decreasing incidents of Naxal violence (from 2,258 in 2009 to 1,412 in 2012). This is the season (before the onset of monsoons) to strike and we want to considerably weaken them through continuous offensive," said a home ministry official.

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Retooling Pap test to spot more kinds of cancer

WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.

Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.

How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.

In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.

This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.

"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.

But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.

The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.

"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.

"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.

But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.

More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.

Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.

The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.

So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.

The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.

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